Pulmonary
Hepatic
Splenic
Hematologic
Gastrointestinal
Neurological
Ophthalmologic
Cardiac
Skeletal
Pulmonary
Respiratory infections
(ie, pneumonia)
Interstitial lung disease
Shortness of breath
Chronic fatigue
Pulmonary hypertension
Hepatic
Hepatomegaly
Fibrosis and cirrhosis
Elevated transaminases
Dyslipidemia
Splenic
Splenomegaly
Abdominal pain, pressure, and early satiety due to splenomegaly
Hematologic
Anemia
Thrombocytopenia (excessive bleeding and easy bruising)
Gastrointestinal
Abdominal pain
Diarrhea
Neurological
Mainly types A and A/B
Hypotonia
Ataxia
Developmental delay
Peripheral neuropathy
Ophthalmologic
Mainly types A and A/B
Cherry red maculae
Cardiac
Mainly types A/B and B
Coronary artery disease
EKG abnormalities
Skeletal
Back, limb, and/or joint pain
Pathologic fractures
Osteopenia/Osteoporosis
Growth delay